Design and Optimization in organic synthesis(elsevier经典)

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Data Handling in Science and Technology---Vol 24

* E, o9 u2 _, w0 ^  ^% c/ ADesign and Optimization in Organic Synthesis
& e% U7 J* I) YBy Rolf Carlson and Johan Carlson

6 ?4 h' k; h8 Z% c/ x8 G5 N" {: @Contents
Chapter 1   Introduction: Strategies on different levels in organic synthesis.
Chapter 2   Experimental study of reaction conditions. Initial remarks.
8 Y7 `3 u! q7 |1 Z4 o% D" w$ mChapter 3   Models as tools.
Chapter 4   General outline of screening experiments.
- K4 Q4 A$ s$ V1 zChapter 5   Two-level factorial designs.
6 }0 P0 ?' S. d# B- [Chapter 6   Two-level fractional factorial designs.
Chapter 7   Other designs for screening experiments.
6 K! s3 A4 u$ r# @( bChapter 8   Summary of screening experiments.
Chapter 9   Optimisation.
) A, m7 f( n$ e8 iChapter 10  Steepest ascent.
Chapter 11  Simplex methods.
4 c8 P8 E: o& `Chapter 12  Response surface methods.
1 M2 `. T! c2 F" V- T/ FChapter 13  Reaction kinetics by sequential response surface modelling.
' L9 H0 f0 h* {# @Chapter 14  Summary of strategies for exploring the experimental space.
Chapter 15  The reaction space.
3 J* j7 n5 [5 @* QChapter 16  Principal properties.
Chapter 17  Strategies for the selection of test systems.
, w& J0 b3 I1 h8 f# M' q- H+ h& yChapter 18  Quantitative relations: Observed responses and experimental variations.
Chapter 19  Exploring discrete variations: Near-orthogonal experiments by singular value.
Chapter 20  Optimisation when there are several response variables.
Chapter 21  A method for determining suitable order of introducing reagents in "one-pot" procedures.
Chapter 22  Books, journals, and computer programs.
* x# ~5 v4 n. }5 h( p7 ]2 }8 pChapter 23  Concluding remarks.
5 O( p$ p7 B& y- z5 i7 a" jAppendix A  Matrix calculus.
Appendix B  Statistical tables
9 e4 k/ _4 b  j, ]) A3 R& x( F共10个压缩卷，解压25.4M

/ P, `. _/ M4 e' z$ F[ 本帖最后由 fenglianxiang 于 2008-8-5 19:47 编辑 ]